DNA methylation plays an important and dynamic role in regulating gene expression. It allows cells to acquire and maintain a specialized state, suppresses the expression of viral and nonhost DNA elements, and facilitates response to environmental stimuli. Aberrant DNA methylation (hyper- or hypomethylation) and its impact on gene expression have been implicated in many normal and aberrant biological processes.
Our Infinium MethylationEPIC and Mouse Methylation BeadChips allow you to interrogate 850,000 or 285,000 markers, respectively, across the genome at single-nucleotide resolution.
Powered by the Infinium assay, the MethylationEPIC BeadChip is ideal for epigenome-wide association studies (EWAS), tumor profiling, and various cell biology experiments. It offers comprehensive, expeert-selected coverage, including 99% of RefSeq genes, 95% of CpG islands, high coverage of enhancer regions, and other content categories. With > 90% of the original content from the Infinium HumanMethylation450K covered, the MethylationEPIC kit supports the next generation of epigenetics research.
Also leveraging the Infinium assay, the Mouse Methylation BeadChip can be used in EWAS and other experiments probing the methylome in healthy and diseased tissues. Much like the MethylationEPIC BeadChip, the Mouse Methylation BeadChip offers genome-wide coverage, with probes targeted to CpG islands, enhancer regions, transcription start sites, and other important regions of the methylome.
MethylationEPIC BeadChip具有用户友好的一体化工作流程，能以低样本起始量（低至250 ng）同时处理多达96个样本。