Infinium MethylationEPIC Kit
可靠的甲基化分析芯片，出色地覆盖了CpG岛、基因和增强子。适用于全表观基因组关联研究。
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Infinium Training
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Infinium Training
20015273
借助Infinium MethylationEPIC BeadChip Kit，研究人员可在单核苷酸水平上定量检测基因组中的超过850,000个甲基化位点。可平行分析包括FFPE在内的多个样本，从而在最大限度地减少每个样本成本的同时实现高通量。
Infinium HD芯片技术能够使内容选择摆脱因甲基化DNA捕获方法的偏差而受到的相关限制。结果包括泛增强子和编码区域的甲基化组图谱，可用于各种人类组织的表观基因组关联研究。
该试剂盒包含甲基化专家要求的以下内容类别:
MethylationEPIC数据分析由GenomeStudio Methylation Module提供支持。GenomeStudio软件可让研究人员轻松为小规模研究进行差异甲基化分析。它特有的高级视图工具，让研究人员能够在单幅图（如热图、散点图和线条图）中查看大量的数据。
这些工具以及GenomeStudio Genome Browser展示了大量有用信息，如染色体坐标、GC百分比、CpG岛的位置，以及甲基化β值。
对于大规模研究而言，现在有许多能在软件框架R语言下运行的免费分析包可供采用，可用于甲基化数据的归一化和差异分析。视频教程介绍了这些数据分析包的用法。
| Infinium MethylationEPIC Kit | TruSeq Methyl Capture EPIC Library Prep Kit | |
|---|---|---|
| Content Specifications | Targets 850,000 CpGs. Quantitatively interrogates selected methylation sites across the genome. | Targets over 3.3 million CpGs. Interrogates biologically important methylome targets. |
| Description | Quantitative interrogation of selected methylation sites across the genome, offering high-throughput research capabilities at a minimal cost per sample. | Focused interrogation of a set of methylome targets for a balanced, cost-effective option that can support both screening studies and biomarker discovery research objectives. |
| Method | Methylation Array | Methylation Sequencing , 靶向DNA测序 |
| Number of Samples | 8 samples per array | Up to 12-plex |
| Specialized Sample Types | FFPE Tissue, Low-Input Samples | Not FFPE-Compatible |
| Technology | Microarray | 测序 |
Technical Note | PDF1 MB
Analyzing FFPE Samples with Infinium Microarrays
Technical Note | PDF< 1 MB
Technical Note | PDF< 1 MB
STM Reagent Improves Robustness of Infinium Methylation Assay
Technical Note | PDF< 1 MB
Infinium Methylation BeadChip Application Note
Application Note | PDF< 1 MB
Application Note | PDF< 1 MB
Infinium MethylationEPIC BeadChip Data Sheet | Illumina
Data Sheet | HTML
Automated bisulfite conversion for Infinium™ Methylation BeadChips
Technical Note | PDF2 MB
BeadArray Controls Reporter Software Guide Documentation
Infinium Assay Consumables and Equipment List Documentation
Infinium HD Methylation Assay Auto Workflow Checklist Documentation
Infinium HD Assay for Methylation Lab Tracking Form Documentation
Infinium HD Methylation Assay Reference Guide Documentation
Infinium MethylationEPIC Kit Support Documentation
Infinium LiHa and Infinium RoMa Operating Manual Documentation
Best Practices for Infinium Assays Documentation
Infinium HD Methylation Assay Manual Workflow Checklist Documentation
自定义协议选择器
Generates customized, end-to-end instructions
The Infinium MethylationEPIC Kit is the recommended replacement product for the HumanMethylation450 BeadChip Kit, which has been discontinued. Illumina remains committed to providing you with high-quality support and service.
Use our interactive tool to find the right Illumina microarray for your project type and method of interest.
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This kit combines next-generation sequencing with epigenetic insights to accelerate biomarker discovery and understand methylation’s role in gene regulation.
Targeted panel that measures expression levels of >20,000 human RefSeq genes.
