Infinium MethylationEPIC Kit

可靠的甲基化分析芯片,出色地覆盖了CpG岛、基因和增强子。适用于全表观基因组关联研究。 Read More...
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What size kit do I need?

Infinium Methylation EPIC BeadChip Kit (8 samples)

20042130

Infinium MethylationEPIC BeadChip Kit (16 samples)

WG-317-1001

Infinium MethylationEPIC BeadChip Kit (32 samples)

WG-317-1002

Infinium MethylationEPIC BeadChip Kit (96 samples)

WG-317-1003

Add-On Content

Infinium MethylationEPIC v1.0 Kit (16 Samples)

20020530

Infinium MethylationEPIC v1.0 Kit (32 Samples)

20020531

Infinium MethylationEPIC v1.0 Kit (96 Samples)

20020532


Services

Infinium Training

20015273

Product Highlights

借助Infinium MethylationEPIC BeadChip Kit,研究人员可在单核苷酸水平上定量检测基因组中的超过850,000个甲基化位点。可平行分析包括FFPE在内的多个样本,从而在最大限度地减少每个样本成本的同时实现高通量。

Infinium HD芯片技术能够使内容选择摆脱因甲基化DNA捕获方法的偏差而受到的相关限制。结果包括泛增强子和编码区域的甲基化组图谱,可用于各种人类组织的表观基因组关联研究。

全面的全基因组覆盖度

该试剂盒包含甲基化专家要求的以下内容类别:

  • CpG岛以外的CpG位点
  • 人类干细胞中鉴定出的非CpG甲基化位点(CHH位点)
  • 肿瘤与正常样本中鉴定出的差异甲基化位点
  • FANTOM5增强子
  • ENCODE开放染色质和增强子
  • DNase超敏位点
  • miRNA启动子区域
整合的分析软件

MethylationEPIC数据分析由GenomeStudio Methylation Module提供支持。GenomeStudio软件可让研究人员轻松为小规模研究进行差异甲基化分析。它特有的高级视图工具,让研究人员能够在单幅图(如热图、散点图和线条图)中查看大量的数据。

这些工具以及GenomeStudio Genome Browser展示了大量有用信息,如染色体坐标、GC百分比、CpG岛的位置,以及甲基化β值。

对于大规模研究而言,现在有许多能在软件框架R语言下运行的免费分析包可供采用,可用于甲基化数据的归一化和差异分析。视频教程介绍了这些数据分析包的用法。

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产品比较

Infinium MethylationEPIC Kit TruSeq Methyl Capture EPIC Library Prep Kit
Content Specifications Targets 850,000 CpGs. Quantitatively interrogates selected methylation sites across the genome. Targets over 3.3 million CpGs. Interrogates biologically important methylome targets.
Description Quantitative interrogation of selected methylation sites across the genome, offering high-throughput research capabilities at a minimal cost per sample. Focused interrogation of a set of methylome targets for a balanced, cost-effective option that can support both screening studies and biomarker discovery research objectives.
Method Methylation Array Methylation Sequencing , 靶向DNA测序
Number of Samples 8 samples per array Up to 12-plex
Specialized Sample Types FFPE Tissue, Low-Input Samples Not FFPE-Compatible
Technology Microarray 测序

具体的方法工作流程范例

 

The Infinium MethylationEPIC Kit is the recommended replacement product for the HumanMethylation450 BeadChip Kit, which has been discontinued. Illumina remains committed to providing you with high-quality support and service.

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