The Infinium OncoArray-500K contains 500,000 SNPs with a genome-wide backbone of 250,000 tag SNPs. Additional SNPs include genetic variants associated with breast, colorectal, lung, ovarian, and prostate cancers plus SNPs covering ancestry, quantitative traits, pharmacogenetics, and fine-mapping of common cancer susceptibility loci. To support additional research requirements, the Infinium OncoArray-500K can be tailored to incorporate up to 120,000 custom beadtypes.*
The Infinium OncoArray-500K was developed in collaboration with leading experts from the OncoArray consortium†, and draws on many of the features of the successful Collaborative Oncological Gene-environment Study (iCOGS) array1. Designed with candidate SNPs identified by the consortium, the OncoArray provides a cost-effective means to assess candidate variants potentially associated with cancer risk.
The Infinium OncoArray-500K uses a 24-sample high-throughput screening (HTS) BeadChip to enable maximum throughput, productivity, and genotyping accuracy. Using the proven iScan System, the Infinium OncoArray-500K is designed to combine affordability with high-density content, providing insight into the relationship between gene variants and cancer predisposition in five of the most prevalent cancers.
* For additional information about custom add-on content, contact your Illumina account manager or sales specialist.
Technical Note | PDF < 1 MB
Infinium Genotyping Data Analysis
Technical Note | PDF 2 MB
Imputation Estimates Genotypes at Un-genotyped Loci
Technical Note | PDF < 1 MB
Infinium Genotyping Data Analysis
Technical Note | PDF 2 MB
Infinium OncoArray-500K BeadChip
Data Sheet | PDF < 1 MB
Infinium LiHa and Infinium RoMa Operating Manual Documentation
Infinium HTS Assay Manual Workflow Checklist Documentation
Infinium HTS Assay Reference Guide Documentation
Infinium HTS Assay Auto Workflow Checklist Documentation
Infinium Assay Lab Setup and Best Practices Documentation
Infinium HTS Automated Lab Tracking Form (15047410) Documentation
Infinium Assay Consumables and Equipment List Documentation
Infinium Onco-Array-500K BeadChip Kit Support Documentation
Infinium HTS Assay Manual Lab Tracking Form (15047409) Documentation
† The OncoArray consortium is an international collaboration of leading experts from the NCI-supported Genetic Association and Mechanisms in Oncology (GAME-ON) consortium, Genome Canada, Genome Quebec, and Cancer Research UK.